Having just developed a plist-based design framework that works in Interface Builder, I’m more interested than ever in using xibs and storyboards to design my views.
I also like using AutoLayout. There are significant advantages when it comes to things like labels that make it so much easier to deal with than manually setting frames everywhere in code. Things like Dynamic Type, accessibility, and localisation all become easier and there’s less room for error.
There are some things that do become more complicated with AutoLayout (mostly transforms) but there are well established workarounds for most of these.
I was recently designing a new app that involved using MapKit and I wanted to use AutoLayout to design a subclsss of MKAnnotationView but this isn’t entirely straightforward.